Aging Brain Center Publications at the Institute for Aging Research

Aging Brain Center Publications


SteelFisher GK, Martin LA, Dowal SL, Inouye SK. Learning from the closure of clinical programs: A case series from the Hospital Elder Life Program.  J Am Geriatr Soc. 2013. In Press. 

Yang FM, Jones RN, Inouye SK, Tommet D, Crane PK, Rudolph JL, Ngo LH, Marcantonio ER.  Selecting optimal screening items for delirium: An application of item response theory.  BMC Medical Research Methodology. 2013; 13(1):8.

Zaubler TS, Murphy K, Rizzuto L, Santos R, Skotzko C, Giordano J, Bustami R, Inouye SK. Quality improvement and cost savings with multicomponent delirium interventions: Replication of the Hospital Elder Life Program in a community hospital. Psychosomatics. 2013. In Press.

Inouye SK, Westendorp RGJ, Saczynski J.  Delirium in Older Persons.  The Lancet. 2013.  In Press.



Gross AL, Inouye SK, Rebok GW, Brandt J, Crane PK, Parisi JM, Tommet D, Bandeen-Roche K, Carlson MC, Jones RN. Parallel but not equivalent: Challenges and solutions for repeated assessment of cognition over time.  J Clin Exp Neuropsychol. 2012. 34:758-72.    PMC3574868

Fong TG, Jones RN, Marcantonio ER, Tommet D, Gross AL, Habtemariam D, Schmitt E, Yap L, Inouye SK. Adverse outcomes after hospitalization and delirium in persons with Alzheimer Disease. Ann Intern Med. 2012;156:848-856. PMC3556489

Saczynski JS*, Marcantonio ER*, Quach L, Fong TG, Gross A, Inouye SK*, Jones RN*. Cognitive trajectories after post-operative delirium. N Engl J Med. 2012; 367:30-39. (these authors made equivalent contributions as first or senior author) PMC3433229

Thomas C, Kreisel SH, Oster P, Driessen M, Volker A, Inouye SK.  Diagnosing delirium in hospitalized elderly patients with dementia: Adapting the Confusion Assessment Method to ICD-10 diagnostic criteria.  J Am Geriatr Soc. 2012. 160:1471-7. PMC3422775

Gross AL, Manly JJ, Pa J, Johnson JK, Park LQ, Mitchell MB, Melrose RJ, Inouye SK, McLaren, DG, for the Alzheimer's Disease Neuroimaging Initiative.  Cortical signatures of cognition and their relationship to Alzheimer's disease.  Brain Imaging and Behavior; 2012. 6:584-9. PMC3553578

Gross AL, Jones RN, Habtemariam D, Fong TG, Tommet D, Quach L, Schmitt E, Yap L, Inouye SK. Delirium and long-term cognitive trajectory among persons with dementia. Arch Intern Med. 2012; 172: 1-8 (on-line early, with editorial). PMID: 23403619

Steis MR, Evans L, Hirschman KB, Hanlon A, Fick DM, Flanagan N, Inouye SK. Screening for Delirium via Family Caregivers: Convergent Validity of the Family Confusion Assessment Method (FAM-CAM) and Interviewer-Rated CAM.  J Am Geriatr Soc. 2012; 60:2121-26. PMC3498543

Morandi A, McCurley J, Vasilevskis EE., Fick DM, Bellelli G, Lee P, Jackson JC, Shenkin SD, Trabucchi M, Schnelle J, Inouye SK, Ely EW, MacLullich AMJ.  Tools to detect delirium superimposed on dementia: A systematic review. J Am Geriatr Soc. 2012; 60:2005-13. PMC3498536

Schmitt EM, Marcantonio ER, Alsop DC, Jones RN, Rogers SO, Fong TG, Metzger E, Inouye SK and the SAGES Study Group*.  Novel risk markers and long-term outcomes of delirium: The Successful Aging after Elective Surgery (SAGES) study design and methods.  J Am Med Dir Assoc. 2012; 13: 818e1-10. PMC3489992.

Wierenga PC, Buurman BM, Parlevliet JL, van Munster BC, Smorenburg SM, Inouye SK, de Rooij SE.  Association between acute geriatric syndromes and medication-related hospital admissions.  Drugs Aging.  2012;  29:691-9 PMID: 22812539

Huang LW*, Inouye SK*, Jones RN, Fong TG, Rudolph JL, O'Connor MG, Metzger ED, Crane PK, Marcantonio ER.  Identifying indicators of important diagnostic features of delirium.  J Am Geriatr Soc 60:1044-1050, 2012. (*these authors made equivalent contributions as first author) PMC3376010



Fong TG, Inouye SK, Dai W, Press DZ, Alsop DC. Association cortex hypoperfusion in mild Dementia With Lewy Bodies: A potential indicator of cholinergic dysfunction? Brain Imaging Behav. 2011 Mar;5(1):25-35

Fong TG, Jones RN, Rudolph JL, Yang FM, Tommet D, Habtemariam D, Marcantonio ER, Langa KM, Inouye SK.  Development and Validation of a Brief Cognitive Asessment Tool:  The Sweet 16.  Arch Intern Med. 2011; 171:432-7 PMID: 21059967.

Leslie DL, Inouye SK.  The importance of Delirium:  Economic and Societal Costs. J Am Geriatr Soc. 2011.  59:S241-243. PMC3415302

Ramaswamy R, Dix EF, Drew JE, Diamond JJ, Inouye SK, Roehl BJ.  Beyond Grand Rounds:  A Comprehensive and Sequential Intervention to Improve Identification of Delirium. Gerontologist. 2011; 51:122-31

Rubin FH, Neal K, Fenlon K, Hassan S, Inouye SK.  Sustainability and Scalability of the Hospital Elder Life Program (HELP) at a Community Hospital.  J Am Geriatr Soc. 2011; 59:359-365.  PMID 21314654.

Chen CC, Lin MT, Tien YW, Yen CJ, Huang GH, Inouye SK.  Modified Hospital Elder Life Program: Effects on abdominal surgery patients.  J Am Coll Surg. 2011; 213:245-252. PMID:21641835

SteelFisher GK, Martin LA, Dowal SL, Inouye SK.  Sustaining clinical programs during difficult economic times: a case series from the Hospital Elder Life Program.  J Am Geriatr Soc. 2011; 59:1873-1882.  PMC3588568

Quinlan N, Marcantonio ER, Inouye SK, Gill TM, Kamholz B, Rudolph JL.  Vulnerability: The crossroads of frailty and delirium.  J Am Geriatr Soc. 2011; 59:S262-268. PMC3233987



Jones RN, Fong TG, Metzger E, Tulebaev S, Yang FM, Alsop DC, Marcantonio ER, Cupples LA, Gottlieb G, Inouye SK. Aging, Brain Disease, and Reserve: Implications for Delirium. Am J Geriatr Psychiatry 2010; 18:117-127. PMC2848522.

Jones RN, Rudolph JL, Inouye SK, Yang FM, Fong TG, Milberg WP, Tommet D, Metzger ED, Cupples A, Marcantonio ER.  Development of a Unidimensional Composite Measure of Neuropsychological Functioning in Older Cardiac Surgery Patients with Good Measurement Precision.  J Clin Exp Neuropsych 2010. May 4:1-9.  PMC2919652.

Rosenbloom-Brunton D, Henneman EA, Inouye SK.  Feasibility of Family Participation in a Delirium Prevention Program for Hospitalized Older Adults.  J Gerontol Nurs. 2010; 36:22-33.

Rudolph JL, Inouye SK, Jones RN, Yang FM, Fong TG, Levkoff SE, Marcantonio ER. Delirium:  An Independent Predictor of Functional Decline After Cardiac Surgery. J Am Geriatr Soc. 2010; 58: 643-649.  PMC2856754. 

Rudolph JL, Zanin NM, Jones RN, Marcantonio ER, Fong TG, Yang FM, Yap L, Inouye SK.  Hospitalization in Community-Dwelling Persons with Alzheimer's Disease: Frequency and Causes.  J Am Geriatr Soc. 2010; 58:1542-1548.  PMC2955171.



Fong TG, Fearing MA, Jones RN, Shi P, Marcantonio ER, Rudolph JL, Yang FM, Kiely DK, Inouye SK.  Telephone Interview for Cognitive Status: Creating a crosswalk with the Mini-Mental State Examination. Alzheimers Dement 2009; 5:492-497. PMC2783323.

Fong TG, Jones RN, Shi P, Marcantonio ER, Yap L, Rudolph JL, Yang FM, Kiely DK, Inouye SK.  Delirium accelerates cognitive decline in Alzheimer's disease.  Neurology.  2009;72:1570-1575.  PMC2677515.

Givens JL, Jones RN, Inouye SK.  The Overlap of Depression and Delirium in Older Hospitalized Patients.  J Am Geriatr Soc. 2009; 57:1347-53. PMC2728175.

Kiely DK, Marcantonio ER, Inouye SK, Shaffer ML, Bergmann MA, Yang FM, Fearing MA, Jones RN.  Persistent delirium predicts increased mortality.  J Am Geriatr Soc. 2009;57:55-61.  PMC2744464.

 Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK.  Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population.  Crit Care Med. 2009; 37:177-83.  PMC2700732.

 Rudolph JL, Jones RN, Levkoff SE, Rockett C, Inouye SK, Sellke FW, Khuri SF, Lipsitz LA, Ramlawi B, Levitsky S, Marcantonio ER. Derivation and Validation of a Preoperative Prediction Rule for Delirium after Cardiac Surgery.  Circulation. 2009;119:229-236. PMC2735244

 Siu AL, Spragens LH, Inouye SK, Morrison RS, Leff B.  Can Chronic Care be Improved Using an Acute Care Platform?  The IronicBusiness Case for Chronic Care.  Health Affairs  2009; 28:113-125.

 Yang F, Marcantonio E, Inouye S, Kiely D, Rudolph J, Fearing M, Jones RN. Phenomenological subtypes of delirium: Patterns,prevalence and prognosis. Psychosomatics.  2009;50:248-254.  PMC2705885.



Agostini JV, Concato J, Inouye SK.  Improving sedative-hypnotic prescribing in older hospitalized patients: Provider-perceived benefits and barriers of a computer-based reminder.  J Gen Intern Med. 2008;23;Suppl 1:32-36.  PMC2150640

 Hshieh TT, Fong TG, Marcantonio ER, Inouye SK.  Cholinergic deficiency hypothesis in delirium:  A synthesis of current evidence. J Gerontol A Biol Sci Med Sci. 2008; 63A:M764-772.  PMC2917793

 Inouye SK, Zhang Y, Jones RN, Shi P, Cupples LA, Calderon HN, Marcantonio ER.  Risk factors for hospitalization among community-dwelling primary care older patients: Development and validation of a predictive model. Med Care. 2008;46:726-731. PMC2516963

Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK.  One-year health care costs associated with delirium in the elderly. Arch Intern Med. 2008;168:27-32.

Marcantonio EM, Aneja J, Jones RN, Alsop DC, Fong TG, Crosby GJ, Culley DJ, Cupples LA, Inouye SK.  Maximizing clinical research participation in vulnerable older persons: Identification of barriers and motivators. J Am Geriatr Soc 2008; 56: 1522-1527. PMC2562594

Rudolph JL, Marcantonio ER, Culley DJ, Silverstein JH, Rasmussen LS, Crosby GJ, Inouye SK.  Delirium is associated with earlypostoperative cognitive dysfunction.  Anaesthesia 2008;63:941-947. PMC2562627

Wei LA, Fearing MA, Sternberg E, Inouye SK.  The Confusion Assessment Method (CAM):  A systematic review of current usage.  J Am Geriatr Soc. 2008;56:823-830.  PMC2585541

Yang FM, Inouye SK, Fearing MA, Kiely DK, Marcantonio ER, Jones RN.  Participation in activity and risk for incident delirium.  J Am Geriatr Soc. 2008;56:1479-1484. PMC2575031



Buss MK, Vanderwerker LC, Inouye SK, Zhang B, Block SD, Prigerson HG. Associations between caregiver-perceived delirium in patients with cancer and generalized anxiety in their caregivers.  J Palliat Med. 2007;10:1083-92. 

Fick DM, Hodo DM, Lawrence F, Inouye SK.  Assessment of nursing recognition of delirium superimposed on dementia using case vignettes.  J Gerontol Nurs 2007;33:40-47.

 Inouye SK, Studenski S, Tinetti ME, Kuchel GA.  Geriatric syndromes:  clinical research, and policy implications of a core geriatric concept.  J Am Geriatr Soc. 2007;55:780-791 (with editorial).  PMC2409147

Inouye SK, Zhang Y, Jones RN, Kiely DK, Yang F, Marcantonio ER.  Risk factors for delirium at hospital discharge:  Development and validation of a predictive model. Arch Intern Med 2007;167:1406-1413.  PMC2516963

McAvay G, Van Ness P, Bogardus S, Zhang Y, Leslie D, Leo-Summer L, Inouye, SK. Depressive symptoms and the risk of incident delirium in older hospitalized adults.  J Am Geriatr Soc. 2007;55:684-691. 

Pisani MA, Murphy TE, Van Ness PH, Araujo KLB, Inouye SK.  Admission characteristics associated with delirium in older patients in a medical intensive care unit.  Arch Intern Med. 2007;167:1629-1634.

Rudolph JL, Jones RN, Rasmussen LS, Silverstein JH, Inouye SK, Marcantonio ER. Independent vascular and cognitive risk factors for postoperative delirium.  Amer J Med. 2007;120:807-813. 



Alsop DC, Fearing MA, Johnson K, Sperling R, Fong TG, Inouye SK.  The role of neuro-imaging in elucidating delirium pathophysiology.  J Gerontol Med Sci. 2006;61A:1287-1293. 

Fong TG, Bogardus ST, Daftary A, Auerbach E, Blumenfled H, Modur S, Leo-Summers L, Seibyl J, Inouye SK. Delirium and Dementia: Cerebral perfusion changes in older delirious patients using 99mTcHMPAO SPECT. J Gerontol Med Sci. 2006;61A:1294-1300.

Inouye SK.  Current concepts:  Delirium in older persons.  N Engl J Med. 2006; 354:1157-1165. 

Inouye SK, Ferrucci L.  Elucidating the pathophysiology of delirium and the inter-relationship of delirium and dementia.  J Gerontol Med Sci. 2006;61A: 1277-1280. PMC2645654

Inouye SK, Zhang Y, Han L, Leo-Summers L, Jones R, Marcantonio E.  Recoverable cognitive dysfunction at hospital admission in older persons during acute illness. J Gen Intern Med  2006;21:1276-1281.  PMC1924736

Jones RN, Yang FM, Zhang Y, Kiely DK, Marcantonio ER, Inouye SK.  Does educational attainment contribute to risk for delirium? A potential role for cognitive reserve.  J Gerontol Med Sci. 2006;61A:1307-1311.

Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK.  Serum biomarkers for delirium. J Gerontol Med Sci. 2006;61A:1281-1286.

Pisani MA, Araujo KLB, VanNess PH, Zhang Y, Ely EW, Inouye SK.  A research algorithm to improve detection of delirium in the intensive care unit.  Critical Care 2006;10:R121.

Xie Z, Dong Y, Maeda, U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: A potential pathogenic link between delirium and dementia.  J Gerontol Med Sci. 2006;61A: 1300-1306. 


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