Douglas P. Kiel, M.D., M.P.H.

Director of Medical Research, Senior Scientist

Contact Information 

Institute for Aging Research
1200 Centre Street
Boston, MA 02131

Phone: 617-971-5373
Fax: 617-971-5339
email: kiel@hsl.harvard.edu

Education

Links

Research Interests and Teaching Activities 

My primary research interests are in the area of osteoporosis and related fractures, including falls, nutritional factors, genetics, and frailty. Much of my work has been carried out in association with the Framingham Study, which includes an ancillary study called the Framingham Osteoporosis Study. In addition, I am interested in clinical trials of pharmacologic and non-pharmacologic interventions to preserve bone mass and prevent fractures.

Keywords

osteoporosis; risk factors; clinical epidemiology; nutrition; genetic epidemiology; accidental falls; clinical trials

Selected Publications

1. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PWF, Ordovas J, Schaefer EJ, Dawson-Hughes, Kiel DP. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 2000;71:1201-1208.
2. McLean RR, Hannan MT, Epstein BE, Bouxsein ML, Cupples LA, Murabito J, Kiel DP. Elderly subjects in cohort studies unable to return for follow up have lower bone mass than those who return. Am J Epidem 2000;151:689-92.
3. Broe KE, Hannan MT, Kiely DK, Cali CM, Cupples LA, Kiel DP. Predicting fractures using bone mineral density: a prospective study of long term care residents. Osteopor Int 2000;11:765-771.
4. Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP. Effect of dietary protein on bone loss in elderly men and women: The Framingham Osteoporosis Study. Am J Bone Miner Res 2000;15:2504-2512.
5. Zee RYL, Myers RH, Hannan MT, Wilson PWF, Ordovas JM, Schaefer EJ, Lindpaintner K, Kiel DP. Absence of linkage for bone mineral density to chromosome 12q12-14 in the region of the vitamin D receptor gene. Calc Tiss Int 2000;67:434-439.
6. Wilson PWF, Kauppila LI, O'Donnell C, Kiel DP, Hannan MT, Polak JM, Cupples LA. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 2001;103:1529-1534.
7. Kiel DP, Kauppila LL, Cupples LA, Hannan MT, O'Donnell CJ, Wilson PWF. Bone loss and the progression of aortic calcification over a 25 year period: The Framingham Heart Study. Calc Tiss Int 2001;68:271-276.
8. Kiel DP Hannan MT, Broe KE, Felson DT, Cupples LA. Can metacarpal cortical area predict the occurrence of hip fracture in women and men over three decades of follow up? Results from the Framingham Osteoporosis Study. J Bone Miner Res 2001;16:2260-2266.
9. Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PWF, Felson DT, Kiel DP. Dietary patterns are associated with bone mineral density in elderly men and women: The Framingham Osteoporosis Study. Am J Clin Nutr 2002;76:245-252.
10. O'Donnell CJ, Chazaro I, Wilson PWF, Fox C, Hannan MT, Kiel DP, Cupples LA. Heritability of abdominal and thoracic aortic calcific deposits in the Framingham Heart Study. Circulation 2002;106:337-341.
11. Karasik D, Myers RH, Cupples LA, Hannan MT, Gagnon DR, Herbert A, Kiel DP. Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham Study. J Bone Miner Res 2002;17:1718-1727.
12. Zhang Y, Kiel DP, Ellison RC, Schatzkin A, Dorgan JF, Kreger BE, Cupples LA, Felson DT. Bone mass and the risk of prostate cancer: The Framingham Study. Am J Med 2002;113:734-739
13. Walsh CR, Cupples LA, Levy D, Kiel DP, Hannan M, Wilson PWF, O'Donnell CJ. Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: The Framingham Study. Am Heart J 2002;144:733-9.
14. Karasik D, Cupples LA, Hannan MT, Kiel DP. Age, gender and body mass effects on quantitative trait loci for bone mineral density: The Framingham Study. Bone 2003;33:308-316.
15. Tan ZS, Seshadri S, Beiser A, Wilson PWF, Kiel DP, Tocco M, D'Agostino RB, Wolf PA. Plasma total cholesterol level as a risk factor for Alzheimer disease: The Framingham Study. Arch Int Med 2003;163:1053-1057.
16. Booth, SL, Broe KE, Gagnon DR, Tucker KL, Hannan MT, McLean RR, Dawson-Hughes B, Wilson PWF, Cupples LA, Kiel DP. Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr 2003;77:512-516.
17. Ferrari SL, Karasik D, Liu J, Karamohamed S, Herbert AG, Cupples LA, Kiel, DP. Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study. J Bone Miner Res 2004;19:552-559.
18. Samelson EJ, Kiel DP, Broe KE, Zhang YQ, Cupples LA, Hannan MT, Wilson PWF, Levy DL, Williams SA, Vaccarino SA. Metacarpal cortical area and risk of coronary heart disease: The Framingham Study. Am J Epidemiol 2004; 159:589-595.
19. McLean R, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP. Plasma homocysteine concentrations predict the risk of hip fracture in elderly men and women: The Framingham Study. New Engl J Med 2004;19:773-781.
20. Tucker KL, Hannan MT, Qiao N, Jacques PF, Selhub J, Cupples LA, Kiel DP. Low plasma vitamin B12 is associated with lower BMD: The Framingham Osteoporosis Study. J Bone Miner Res 2005;20:152-158.
21. Tan ZS, Seshadri S, Beiser A, Zhang Y, Felson DT, Hannan MT, Rhoda A, Wolf PA, Kiel DP. Bone mineral density and the risk of Alzheimer's disease. Arch Neurol 2005;62:107-111.