Foot Disorders and Foot Pain Research

Foot Disorders and Foot Pain Research

Foot pain and certain foot disorders are very common in the general population, with disability related to these foot problems also a frequent occurrence in the community. Population-based studies indicate of the 25% of men and women with foot pain, approximately two-thirds report at least moderate disability. Foot disorders have been shown to have a detrimental impact on health-related quality of life across a spectrum of age-groups. Risk factors include increased age, being female, improperly fitting shoes, obesity and chronic medical conditions such as osteoarthritis and diabetes. Despite the high prevalence and significant impact of foot pain, relatively little is known about the underlying risk factors for its development.

Foot Disorders, Pain and Physical Disability in Older Persons: the Framingham Foot Study
NIAMS R01 AR047853

The overall goal of this project is to examine the effect of age, sex, and race upon biomechanical foot measures, and to examine the relation of these measures to lower extremity limitations and functional disabilities in two, large population-based cohorts of older adults.  This renewal 5-year NIH grant builds upon a previous 5-year project that examined specific foot disorders.  Over 3,000 adults are enrolled in these cohorts, incorporating information from diverse environments (urban vs rural) and from various racial/ethic groups.

Genetics of Foot Disorders
NIAMS R01 AR060492

This grant will examine the heritability of specific foot disorders and conduct GWAS of foot disorders and foot biomechanics in two large population-based cohorts, the Framingham Study and Johnston County OA Project. Meta-analyses across the known cohorts with these phenotypes will be conducted and SNP findings will be replicated in other cohorts with foot and genetic data.
This is the first human GWAS of foot disorders and the investigators welcome contact from others across the world interested in the genetics of foot disorders in populations.

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