Osteoporosis, Fractures and Falls Research

Osteoporosis, Fractures and Falls Research

Osteoporosis is considered a major public health threat for an estimated 44 million Americans, or half of those aged 50 and older. An estimated 10 million in the U.S. already have the disease. Women are at higher risk than men. Another 34 million Americans have low bone density, putting them at increased risk for osteoporosis and fractures, especially of the hip, spine and wrist. About one-quarter of those who suffer a hip fracture die within a year of the injury. Osteoporosis-related fractures were responsible for an estimated $19 billion in health care costs in 2005, with that figure expected to increase to $25 billion by 2025.

Bone Microarchitecture:  The Framingham Osteoporosis Study 
NIAMS NIAMS R01 AR061445-01

After performing high resolution peripheral quantitative computed tomography scans on over 2,500 Framingham Study participants, the microarchitectural indices obtained from the images will be used to perform genome wide association studies, to study risk factors for bone microarchitecture, and to determine if bone microarchitecture predicts fracture.
Low Magnitude Mechanical Stimulation to Improve BMD
NIA  R01 AG025489

This is a randomized, double-blind, placebo-controlled trial of low magnitude mechanical simulation with whole body vibration to improve bone mineral density as measured by quantitative computed tomography (QCT) of the hip and spine and to determine the effect of the intervention on biochemical markers of bone turnover in seniors treated with 10 minutes per day of whole body vibration (0.3g, 30 Hz).

Predicting Hip Fracture using a Biomechanical Approach
NIAMS R01 AR060816

The specific goal of this study is to investigate the contribution of trochanteric soft tissue thickness to hip fracture risk, and to include this in the biomechanical Factor-of-Risk model. We hypothesize these factors predict hip fracture, and further that the factor-of-risk prediction of hip fracture risk will prove better than BMD assessment alone and better than the World Health Organization FRAX tool.           

Risk Factors for Age Related Bone Loss

This is the fourth, 5-year continuation of this project examining both genetic and lifestyle factors influencing age-related bone loss and fractures. The project involves the performance of a genome-wide association study of genes responsible for bone density and quantitative ultrasound.  It also examines diet by gene interactions and the role of lean leg mass on the risk of hip fracture.

A Phase III Randomized, Placebo-Controlled Clinical Trial to Assess the Safety and Efficacy of Odanacatib (MK-0822) to Reduce the Risk of Fracture in Osteoporotic Postmenopausal Women Treated With Vitamin D and Calcium
Merck Sharp and Dohme

This is a multi-center randomized, placebo controlled clinical trial of a cathepsin K inhibitor to prevent fractures and increase bone mineral density in postmenopausal women.

Inflammatory factors and their role in the relation between estrogen and bone mineral density: an epidemiologic approach in the Framingham Osteoporosis Study.
American College of Rheumatology Research and Education Foundation Health Professional New Investigator Award   

The purpose of this longitudinal cohort study is to determine the influence of plasma concentrations of inflammatory biomarkers (CRP, IL-6, TNF-α) on bone density in the Framingham Study, as well as investigate their potential role in the relation between estrogen and age-related bone loss.

Medications as Acute Precipitants of Falls in the Nursing Home Setting.
NIA  AG033204 

This is a mentored career development award to comprehensively examine the acute effects of medication changes on the risk of falls in the nursing home setting.  Medication classes of interest include antidepressants, antipsychotics, benzodiazepines, other sedative hypnotics, diuretics, and opioids. The educational curriculum focuses on study methodology, falls epidemiology, and pharmacoepidemiology.

Protein Food Clusters and Measures of Bone Mineral Density and Muscle Strength.
Harvard Translational Research in Aging training Program, NIA T-32 grant

The goal of this study is to investigate the relation of protein food groups (as defined by cluster analysis) with bone mineral density and muscle strength using the data from the Framingham Osteoporosis Study.

Associations of Dairy Foods and Dairy Nutrient with Bone Health: The Framingham Study
Unrestricted grant funding from the General Mills Bell Institute of Health and Nutrition 

The aim of this project is to determine the associations of dairy food group variables, including total dairy foods and individual foods such as milk, yogurt and cheese, and will consider dairy related nutrients including calcium, magnesium, phosphorus, vitamin D and protein with bone mineral density, bone loss and hip fracture risk in older adults from the Framingham Osteoporosis Study.

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