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Robert R. McLean, D.Sc., M.P.H.
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Research Assistant Scientist II
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 Contact Information
Institute for Aging Research
1200 Centre Street
Boston, MA 02131
Phone: 617-971-5376
Fax: 617-971-5339
email: rmclean@hsl.harvard.edu
Education
| 1995 |
B.S. |
Rensselaer Polytechnic Institute; Troy, NY |
| 1998 |
M.P.H |
Boston University School of Public Health; Boston, MA |
| 2006 |
D.Sc. |
Boston University School of Public Health; Boston, MA |
Links
Pubmed
Research Interests and Teaching Activities
Primary research interests lie in elucidating the causes of osteoporosis and related fractures, with particular focus on 1) homocysteine, B vitamins and their potential roles in the etiology of bone loss and fractures; 2) nutritional risk factors for osteoporosis and how they interact with genes to influence bone health; and 3) the identification of risk factors for falls and resulting hip fractures among elders. Dr. McLean's teaching activities include leading tutorials for the Clinical Epidemiology course for first-year medical students at Harvard Medical School (AC701) and serving as a teaching assistant for Intermediate Epidemiology at the Boston University School of Public Health. He has been a guest lecturer on the nutritional epidemiology of osteoporosis at Boston University, presented hospital grand rounds on evidence-based medicine and critical appraisal of research proposals, and has led sessions at annual scientific meetings on epidemiologic methods and the interpretation of research studies.
Keywords
Osteoporosis, hip fracture, homocysteine, B vitamins, dietary risk factors, gene-nutrient interactions, epidemiologic methods
Selected Publications
- McLean RR, Hannan MT, Epstein BE, Bouxsein ML, Cupples LA, Murabito J, Kiel DP. Elderly cohort study subjects unable to return for follow-up have lower bone mass than those who can return. Am J Epidemiol 2000; 151:689-92.
- Booth SL, Broe KE, Gagnon DR, Tucker KL, Hannan MT, McLean RR, Dawson-Hughes B, Wilson PWF, Cupples LA, Kiel DP. Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr 2003; 77:512-6.
- McLean RR, Karasik D, Selhub J, Tucker KL, Ordovas JM, Russo GT, Cupples LA, Jacques PF, Kiel DP. Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J Bone Miner Res 2004; 19: 410-8.
- McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004; 350: 2042-9.
- McLean RR, Booth SL, Kiel DP, Broe KE, Gagnon DR, Tucker KL, Cupples LA, Hannan MT. Association of dietary and biochemical measures of vitamin K with quantitative ultrasound of the heel in men and women. Osteoporos Int 2006; 17: 600-7.
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