Yi-Hsiang (Sean) Hsu, Sc.D.

Research Assistant Scientist II

Contact Information

Institute for Aging Research
1200 Centre Street
Boston, MA 02131

Phone: 617-971-5368
Fax: 617-971-5339
email: Yi-HsiangHsu@hsl.harvard.edu

Education

Research Interests and Teaching Activities

My research focuses on the genetics, environmental risk factors, and their interactions of complex diseases (including osteoporosis, metabolic syndrome, hypertension and type 2 diabetes), pharmacogenetics, and proteomics. I am actively involved in studies that are designed to examine the genetic and environmental determinants of bone mineral density using genome-wide scan linkage analysis and family-based association design. I am also involved in a genetic association study for type 2 diabetes in several prospective cohorts. Additionally, I am collaborating in a project of protein expression profile (proteomics) of placental tissues examined in pre-term deliveries. My other major interests are in the methodology of genetic association studies and bioinformatics. I also have experience of several laboratory techniques, especially for high throughput genotyping, gene expression, and cell culture.

Keywords 

Genetics, osteoporosis, hypertension, metabolic syndrome, type 2 diabetes, pharmacogenetics, proteomics

Selected Publications

1. Hsu YH, Venners SA, Terwedow H, Niu T, Feng Y, Bouxsein M, Betensky R, Laird N, Brain J, Cummings SR, Rosen C, Xu X. Relationship of body composition, fat mass and serum lipids to osteoporotic fractures and bone mineral density in men and women. Amer J Clin Nutr 2006; 83: 146-154.
2. Hsu YH, Niu T, Terwedow H, Xu X, Feng Y, Bouxsein M, Brain J, Betensky R, Laird N, Rosen C, Xu X. Genetic variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Human Genetics 2006; 118: 568-577.
3. Hsu YH, Xu X, Terwedow H, Bouxsein M, Cummings SR, Rosen CJ, Brain J, Xu X. A large-scale genome-wide linkage analysis for loci linked to bone mineral density at different skeletal sites in extreme selected sibships. Journal of Bone and Mineral Research 2007; 22:184-94
4. Hsu YH, Li SY, Chiou HY, Yeh PM, Hsueh YM and Chen CJ. Spontaneous and induced sister chromatid exchanges and delayed cell proliferation in peripheral lymphocytes of Bowen's disease patients and matched controls of arseniasis-hyperendemic villages in Taiwan. Mutation Research-Reviews in Mutation Research 1997;386:241-251.
5. Zalloua PA, Hsu YH, Terwedow H, et al. Impact of seafood and fruit consumption on bone mineral density in women. Maturitas 2007; 20;56(1):1-11.