Yue Fang M.D. Ph.D

Research Fellow

Contact Information

Institute for Aging Research
1200 Centre Street
Boston, MA 02131

Phone: 617-971-5364

Fax: 617-971-5339

Email: fangyue@hsl.harvard.edu  

Links

PubMed Articles

Research Interests

Dr. Fang's research experience has been focusing on multi-disciplinary approaches (including methods of molecule genetics, bioinformatics, biostatistics, genetic epidemiology, and cell biology) to investigate the relationship between genetic variations and different phenotypes (diseases, including myocardial infarction, osteoporosis, Parkinson's disease and other aging-related disorders). On the one hand, he combines different methods and techniques for human genetic study. On the other hand, his research topic of the human genetics is extending, from the study for variants in one candidate gene (VDR gene), then to variants at several genes in a certain biological pathway (dopamine metabolic pathway for Parkinson's disease), and up to now for variants across the whole human genome. Further study is to identify functional sequence variants for diseases. His current research work in the Harvard Medical School focuses on further studies around and post genome-wide association study (GWAS).  To study closely some interesting regions according to GWAS, He will use approaches, like candidate gene approach, next generation re-sequencing approach to characterize potential functional variations for disease or interesting phenotypes. Studies will employee the Framingham study cohort and some large-scale study cohorts from international consortia.  

Keywords
Human Genetics, epidemiology, environment, aging, osteoporosis

Selected Publications

1. Yue Fang, Joyce B. J. van Meurs, Pascal Arp, Johannes P. T. van Leeuwen, Albert Hofman, Huibert A. P. Pols, André G. Uitterlinden (2009) Vitamin D Binding Protein genotype and Osteoporosis. Calcif Tissue Int. 2009 85: 85-93.

2. Zhang YP, Deng FY, Chen Y, Pei YF, Fang Y, Guo YF, Guo X, Liu XG, Zhou Q, Liu YJ, Deng HW (2009) Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening Osteoporos Int. 2009 June.

3. D. Verbaan, S. Boesveldt, S.M. van Rooden, M. Visser, J. Marinus, M.G. Macedo, Y. Fang, P. Heutink, H. Berendse, and J.J. van Hilten (2008); Is olfactory impairment in Parkinson's disease related to phenotypic or genotypic characteristics? Neurology 71(23):1877-82.(Impact factor: 6.0)

4. Maria G. Macedo, Dagmar Verbaan, Yue Fang, Stephanie M. van Rooden, Martine Visser,  Burcu Anar, Antonella Uras, Justus L. Groen, Patrizia Rizzu, Jacobus J. van Hilten, Peter

   Heutink (2008) Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease;  Movement Disorders (impact factor: 3.3)

5. Fang Y, van Meurs JB, Rivadeneira F, van Schoor NM, van Leeuwen JP, Lips P, Pols HA, Uitterlinden AG (2007) Vitamin D receptor gene haplotype is associated with body height and bone size. J Clin Endocrinol Metab 92:1491-1501. 2007 92(4):1491-501. (impact factor: 5.8)

6. Uitterlinden AG, Ralston SH, Brandi ML, Carey AH, Grinberg D, Langdahl BL, Lips P, Lorenc R, Obermayer-Pietsch B, Reeve J, Reid DM, Amidei A, Bassiti A, Bustamante M, Husted LB, Diez-Perez A, Dobnig H, Dunning AM, Enjuanes A, Fahrleitner-Pammer A, Fang Y, Karczmarewicz E, Kruk M, van Leeuwen JP, Mavilia C, van Meurs JB, Mangion J, McGuigan FE, Pols HA, Renner W, Rivadeneira F, van Schoor NM, Scollen S, Sherlock RE, Ioannidis JP, Investigators A, Investigators E, Investigators E, Investigators F, Investigators L, Rotterdam Study I, Study G (2006) The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Annals of Internal Medicine 145(4):255-64. (impact factor: 14.8)

7. Fang Y, Rivadeneira F, van Meurs JB, Pols HA, Ioannidis JP, Uitterlinden AG (2006) Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. Bone 39:938-945. (impact factor: 4.1)

8. Fang Y, van Meurs JB, d'Alesio A, Jhamai M, Zhao HY, Rivadeneira F, Hofman A, van Leeuwen J, Jehan F, Pols HA, Uitterlinden AG. (2005) Promoter and 3'-UTR haplotypes in the vitamin D receptor (VDR) gene predispose to osteoporotic fracture: The Rotterdam Study. Am. J. Hum. Genet, 77:807-823. (impact factor: 12.6)

9. Claassen M, Nouwen J, Fang Y, Ott A, Verbrugh H, Hofman A, van Belkum A, Uitterlinden A (2005) Staphylococcus aureus nasal carriage is not associated with known polymorphism in the Vitamin D receptor gene. FEMS Immunol Med Microbiol 43(2):173-176.

10. Uitterlinden AG, Arp PP, Paeper BW, Charmley P, Proll S, Rivadeneira F, Fang Y, van Meurs JB, Britschgi TB, Latham JA, Schatzman RC, Pols HA, Brunkow ME (2004) Polymorphisms in the Sclerosteosis/van Buchem Disease Gene (SOST) Region Are Associated with Bone-Mineral Density in Elderly Whites. Am J Hum Genet 75(6):1032-45. (impact factor: 12.6)

11. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338(2):143-56. (impact factor: 2.7)

12. Uitterlinden AG, Fang Y, Van Meurs JB, Van Leeuwen H, Pols HA (2004) Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol 89-90:187-93. (impact factor: 2.8)

13. Schuit SC, van Meurs JB, Bergink AP, van der Klift M, Fang Y, Leusink G, Hofman A, van Leeuwen JP, Uitterlinden AG, Pols HA (2004) Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms. J Clin Endocrinol Metab 89(1):303-9. (impact factor: 5.8)

14. van Meurs JB, Schuit SC, Weel AE, van der Klift M, Bergink AP, Arp PP, Colin EM, Fang Y, Hofman A, van Duijn CM, van Leeuwen JP, Pols HA, Uitterlinden AG (2003) Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. Hum Mol Genet 12(14):1745-54. (impact factor: 8.1)

15. Fang Y, van Meurs JB, Bergink AP, Hofman A, van Duijn CM, van Leeuwen JP, Pols HA, Uitterlinden AG (2003) Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly. J Bone Miner Res 18(9):1632-41. (impact factor: 6.6)

16. Colin EM, Uitterlinden AG, Meurs JB, Bergink AP, van de Klift M, Fang Y, Arp PP, Hofman A, van Leeuwen JP, Pols HA (2003) Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. J Clin Endocrinol Metab 88(8):3777-84. (impact factor: 5.8)

17. Bergink AP, van Meurs JB, Loughlin J, Arp PP, Fang Y, Hofman A, van Leeuwen JP, van Duijn CM, Uitterlinden AG, Pols HA (2003) Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. Arthritis Rheum 48(7):1913-22. (impact factor: 7.7)

18. Uitterlinden AG, Fang Y, Bergink AP, van Meurs JB, van Leeuwen HP, Pols HA (2002) The role of vitamin D receptor gene polymorphisms in bone biology. Mol Cell Endocrinol 197(1-2):15-21. (impact factor: 2.9)

19. Kann P, Bergink AP, Fang Y, Van Daele PL, Hofman A, Van Leeuwen JP, Beyer J, Uitterlinden AG, Pols HA (2002) The collagen Ia1 SP1 polymorphism is associated with differences in ultrasound transmission velocity in the calcaneus in postmenopausal women. Calcif Tissue Int 70(6):450-6. (impact factor: 2.5)

20. Havelka S, Uitterlinden AG, Fang Y, Arp PP, Pavelkova A, Vesela M, Halman L, Forejtova S, Ruzickova S, Pavelka K (2002) Collagen type I(alpha 1) and vitamin D receptor polymorphisms in diffuse idiopathic skeletal hyperostosis. Clin Rheumatol 21(4):347-8. (impact factor: 1.4)

21. Uitterlinden AG, Weel AE, Burger H, Fang Y, van Duijn CM, Hofman A, van Leeuwen JP, Pols HA (2001) Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture. J Bone Miner Res 16(2):379-85. (impact factor: 6.6)

22. van Meurs JB, Arp PP, Fang Y, Slagboom PE, Meulenbelt I, van Leeuwen JP, Pols HA, Uitterlinden AG (2000) Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat. Electrophoresis 21(17):3571-7. (impact factor: 4.1)

23. Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FE, Grant SF, Hofman A, van Leeuwen JP, Pols HA, Ralston SH (1998) Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338(15):1016-21. (impact factor: 52.6)